The Physiological and Therapeutical Effects of Carbolic Acid Administered Internally

I secured two pariah dogs, about the size of greyhounds, put them on the ordinary full diet of a patient, and commenced, on the 19th April last, with one minim doses to each dog, three times a day. On the 21st, I gave 2 minims, three times ; on the 23rd, increased it to 3 minims, which I continued to give three times a day until the 1st May. I then increased the dose to five minims, three times a day, and on the 5 th to 8 minim doses. On the 7th, I gave each day, 10 minims, three times, and as I was obliged to leave the station for some days, let them both loose until my return. In eighteen days each dog took 225 minims without showing that it had had the least effect on him: no thirst appeared to be induced, nor any apparent discomfort, and they ate their food regularly. I returned to the station on the 14th and caught the same dogs, and recommenced my experiment on the 15th, by giving 10 minims, three times a day, to each. On the 16th, I gave 12 minims, and on the 17th, 15 minims, three times during the day. On the 18th, after the third or evening dose, it was